Ropinirolum [INN-Latin]

Ropinirolum [INN-Latin] Brand names, Ropinirolum [INN-Latin] Analogs

Ropinirolum [INN-Latin] Brand Names Mixture

No information avaliable

Ropinirolum [INN-Latin] Chemical_Formula

C₁₆H₂₄N₂O

Ropinirolum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/ropinirole.htm

Ropinirolum [INN-Latin] fda sheet

Ropinirolum_[INN-Latin] FDA

Ropinirolum [INN-Latin] msds (material safety sheet)

Ropinirolum_[INN-Latin] MSDS

Ropinirolum [INN-Latin] Synthesis Reference

No information avaliable

Ropinirolum [INN-Latin] Molecular Weight

260.375 g/mol

Ropinirolum [INN-Latin] Melting Point

243-250 ^oC

Ropinirolum [INN-Latin] H₂O Solubility

133 mg/mL

Ropinirolum [INN-Latin] State

Solid

Ropinirolum [INN-Latin] LogP

2.72

Ropinirolum [INN-Latin] Dosage Forms

Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

Ropinirolum [INN-Latin] Indication

For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

Ropinirolum [INN-Latin] Pharmacology

Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D₂ subfamily of dopamine receptors, binding with higher affinity to D₃ than to D₂ or D₄ receptor subtypes. The relevance of D₃ receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D₂ -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

Ropinirolum [INN-Latin] Absorption

Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

Ropinirolum [INN-Latin] side effects and Toxicity

Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

Ropinirolum [INN-Latin] Patient Information